Immunisering mot Gonadotropin-releasing hormone (GnRH) har visat sig vara effektivt mot att hämma galtlukt på griskött och oönskat aggressivt beteende bland hangrisar. I ett samhälle där vi sätter allt högre krav på våra produktionsdjurs välfärd är efterfrågan på metoder som inte innebär smärta eller lidande för djuren stor. Det finns dessutom positiva produktionsrelaterade effekter med immunokastrering gentemot klassisk kirurgisk kastrering, såsom ökad tillväxtpotential. Faktorer som dessa talar för immunokastrering, men samtidigt finns många svårigheter med att vaccinera mot något kroppseget och således bryta kroppens tolernas mot självt. Den här litteraturstudien behandlar svårigheterna med att rikta ett vaccin mot ett endogent hormon, vad som har lett fram till dagens upptäckter och de eventuella problem som kan uppstå i framtiden.

The castration of piglets is performed routinely all around the world. Most castrations are done without anaesthesia and analgesia, despite the fact that this procedure has been proved to induce acute pain and stress for the piglets. The procedure regarding castration of piglets is currently a hot topic of debate and an important political issue. The underlying issue is the boar taint which are highlighted in the heating of the meat after slaughter, which in turn can lead to reduced meat sales as it can be perceived as unpleasant for many consumers. The purpose of this study is to examine alternative drugs which may be selected in order to replace the practice of castration of piglets without anaesthesia, in light of improved animal welfare.

This article presents a survey of male dogs treated with the gonadotropin releasing hormone (GnRH) agonist deslorelin (Suprelorin®, Virbac) at three animal clinics in central Sweden. Filled-in questionnaires from 110 dogs were received. The paper also includes a review of existing litterature concerning reproduction in male dogs, focusing on endocrinology, the effects of gonadectomy and the GnRH agonist deslorelin. Continuous treatment with deslorelin produces infertility in male dogs. The pituitary is initially stimulated by deslorelin leading to a rise in luteinizing hormone (LH) and follicle stimulating hormone (FSH) secretion. As a consequence the testosterone levels also increase temporarily.

This study has been made to evaluate if there is a significant difference between non-estral intact versus ovariohysterectomized queens in their production of estradiol after exogenous gonadotrophin-releasing hormone stimulation. The purpose is to find a tool, which can help to diagnose if a free-roaming queen is already ovariohysterectomized or not. There are also other situations where this tool could be useful, for example to diagnose the ovarian remnant syndrome. Previous studies in bitches have shown that GnRH-stimulation is an excellent tool to diagnose the presence of ovaries in the bitch. Eleven ovariohysterectomized and eleven intact queens have been included in this study where we have analyzed plasma estradiol and progesterone concentrations before and after a single intramuscular injection of the GnRH agonist buserelin (Receptal?).

Active immunization against Gonadotropin-releasing hormone (GnRH) is an alternative to surgical castration of male pigs to avoid boar taint. The aim of this study, including 128 pigs, was to evaluate the effect of a GnRH-vaccine Improvac® on performance and on social and sexual behaviour. Male pigs were assigned to three treatments; surgical castration at four days of age, immunization against GnRH and no castration. Vaccination was performed eight and four weeks before slaughter. Surgically castrated male pigs had significantly lower daily weight gain during the suckling period than entire male pigs (235 vs.

Kastrering av smågris för att motverka galtlukt görs idag i Sverige under grisens första levnadsvecka utan bedövning. EU kommissionen har lagt fram ett förslag på att från och med 2012 ska all kastrering av grisar ske med bedövning, och kirurgisk kastrering ska upphöra från 2018 under förutsättning att vissa praktiska problem har lösts tills dess. Olika alternativ till dagens kastrering är således ett mycket aktuellt problem och ett av alternativen till detta är immunokastrering. Immunokastrering sker genom att man vaccinerar grisen mot ett endogent hormon, GnRH (gonadotropin releasing hormone), vilket hämnar testikelns funktion och minskar bildning av galtluktsämnena androstenon, skatol och indol. Denna litteraturstudie är inriktad på hur immunokastrering påverkar grisarna ur produktionssynpunkt med fokus på kött- och fetthalt, beteende, foderåtgång och andra problem som diskuteras kring den praktiska tillämpningen av immunokastrering på gris i Sverige. Studien visar att immunokastrerade grisar har högre kötthalt, lägre fetthalt och mindre foderåtgång än kirurgiskt kastrerade grisar.

Male piglets have been castrated for centuries to avoid contamination of their meat with boar taint, a strongly unpleasant odour that makes the meat inedible. Today boar taint can be prohib-ited by vaccination against gonadotropin releasing hormone (GnRH) using Improvac®. The aim of this study was to evaluate the efficiency of vaccination on growth performance and behaviour of vaccinated male pigs compared to surgically castrated male pigs. The effect of two feeding regimes, restricted (SLU-norm) and semi ad libitum, was also included in the study. At birth, pigs (n=206) were randomly allocated to the two treatment groups; surgically castrated and vaccination.

Oxytocin is today widely spoken of as a "feel good" hormone. Recent research has increased interest in the hormone and its role in social and sexual interactions, as well as its importance for complex behavioral patterns. There is evidence that oxytocin is released during physical contact and is said to suppress anxiety and stress. In animals and humans, oxytocin, which is a neuropeptide and likewise a hormone, is necessary for parturition and lactation. Synthesis of oxytocin occurs in brain neurons and in specific organs involved in reproduction.

The aim of this study was to explore transsexuals? identity formation and experiences related to cross-sex hormone treatment, as well as to become absorbed in the narrative approach. To be able to participate in transsexuals? identity formation, life stories were well suited as a theoretical approach. Life stories can be seen as socially situated actions according to Mishler, where individuals? identity formation can be seen as both identity performances and identity claims.

In this essay dog as a compatible model were put against human. The major histocompatibility complex (MHC) genes were compared between dogs, human, cat and mouse. To evaluate dog as a model and study similarities and differences was the aim with this review. Dog as a model contributes to understand mechanisms behind autoimmune diseases and showed clearly histological similarities between human and dogs concerning the skin disease mucous membrane pemphigoid (MMP)/cicatricial pemphgioid (CP). Further genetic evidence motivated the choice of using dog as a comprehensive model when the MHC-complex correlated with hypothyroiditis in Doberman dog as it does in human. Physiological similarities with low levels of thyroid hormones (T3 and T4) together with high level of thyroid releasing hormone (TSH) were found in the same way as in human.

Picropodophyllin (PPP) is an analogue of the anti tumour lignan podophyllotoxin with the unique ability to selectively inhibit the receptor of Insulin like growth factor 1(IGF-1). IGF-1 is believed to play an important part in development of the endometrium facing implantation. With PPP treated mice, studies can be made to measure gene expression from tissue of both treated and untreated mice to compare the role of IGF-1 regarding ovulation, implantation and receptivity. The aim of this study was to analyze gene expression of some steroid hormone receptors and cytokines in ovaries from mice treated with PPP. In this study, seven mice were treated with PPP at different times and tissue was collected.

This BSc thesis is a part of an initial step of a collaboration between Skansen and Kenyan Wildlife Service (KWS) and constitutes of an inventory of the Nairobi Animal Orphanage run by KWS. Animal Orphanage takes care of orphaned and injured animals arriving from throughout Kenya. The project started out as a refuge and as a temporary place for animals in need of care and help. With time it has evolved to an establishment that resembles and functions more like an animal zoo. The aim of this inventory is to focus on how the biological needs of Congo grey parrots ( Psittacus erithacus erithacus) and cheetahs (Acinonyx jubatus) are met, in terms of management and housing.

Background: Testosterone is the most important androgenic hormone in the male. Aging is closely associated with reduction of serum testosterone which can lead to reduced muscle mass, muscle strength, bone density, and depression. These symptoms may be counteracted by administration of testosterone. Objective: The purpose of this study was to examine the effects of hormone replacement in men with age-related testosterone deficiency. Method: We performed a systematic review using Randomised Controlled Trials (RCT).

ABSTRACTA defect implantation process is the major reason for unexplained infertility. Estrogen andprogesterone are steroid hormones preparing the endometrium for implantation. They mediatetheir effect through their receptors: estrogen receptor alpha and beta and progesteronereceptor A and B, respectively. Leukemia inhibitory factor (LIF), which is also important forimplantation, mediates its effect through LIF receptor and the coreceptor, gp130, and is downregulated by suppressors of cytokine signaling 1. The aim of the study was to compare thelevels of the steroid hormone receptors and LIF related factors in the endometrium of twogroups of women with the diagnosis unexplained infertility: one that became pregnant afterassisted reproduction and one that did not become pregnant.

This article presents a retrospective case study combined with a review of the current literature concerning canine gestational diabetes. A total of 14 cases have been collected from six different clinics in Sweden. There are few previously published reports on canine gestational diabetes. Gestational diabetes is a disease that rarely occurs in pregnant bitches. The condition is due to the rise of progesterone that occurs during the estrus cycle.